IMMM characterizes nanoparticles using SERS

The Institute of Molecules and Materials of Le Mans (IMMM) is in charge of the characterization of the optical and plasmonic properties of the nanostructures included in the bioanalytical platform. It also determines the SERS efficiency and the sensing performances of the platform. Finally, it is involved in the validation of the sensor for food and biomedical applications.

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CIC biomaGUNE creates plasmonic particles and sensing elements

DeDNAed partner CIC biomaGUNE is responsible for design, synthesis, and characterization of different sensing biorecognition elements (antibodies and DNA aptamers) in pure state and modified with metallic and semiconductor atomic clusters. They also design, synthesize, and provide metallic nanoparticles of different size and shape as amplifiers of optical read out signals.

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TechForum Millstatt, 3-7 June 2024, Millstatt, AT

Save the date for the TechForum Millstatt which will tak place from  3 – 7 June 2024 in Millstatt, Austria.

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BioCHIP 2024, 28-29 May 2024, Berlin, Germany

BioCHIP Berlin focuses on technologies and applications of microfluidic platforms, fabrication techniques, system integration and emerging applications for life sciences.

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DeDNAed @ MAIN Focus Day on Quantum Dots

The MAIN research center at the Technical University of Chemnitz (TUC) hosted its MAIN Focus Day on Quantum Dots on 18 January 2024.

The event consisted of 2 research seminars held at the MAIN facilities and a colloquium in the central auditorium.

Julia Hann presented a poster showing the possibility of integrating quantum dots with the DNA origami on surfaces, using the example of our activities in nanoparticles and biomolecules with DeDNAed.

More information about the event (in German) can be found here.

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DeDNAed @ BNN Quarterly (Dec 2023)

DeDNAed was featured in the latest BNN QUARTERLY issue (Dec 2023), our “Digital Magazine for Developments in Sustainable Technology” with an article about “DeDNAed Meeting and Interactive Training of the Consortium”.

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ANTHOS 2024, 4-7 March 2024, Vienna

The “Advanced (Nano)Materials and Technologies: science, research & innovation for safety and sustainability” Summit 2024 (ANTHOS 2024) promotes the advancements in technological innovation & research results on Safe-by-Design (SbD) for advanced (nano)materials and beyond.

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First Joint Publication for DeDNAed

In the field of medical diagnostics, the identification and measurement of biomarkers have become essential tools for early disease detection and treatment monitoring.

Within DeDNAed, Le Mans Université (France) and the research centre TECNALIA Research & Innovation (Spain) focus their research on the detection of interleukin-6, a cytokine which can be used to monitor various human diseases and treatment responses. Conventional assays, such as ELISAs, are time-consuming and require large sample volumes. Therefore, the development of a fast, sensitive and selective detection method is critical.

Researchers from DeDNAed proposed a sensing method based on the surface-enhanced Raman scattering (#SERS), a technique that emerges as a promising alternative for the highly sensitive IL-6 detection.

They developed a label-free SERS immunoassay, achieving an impressive limit of detection of 0.91 pg mL−1 (0.04 pM), ten times lower than ELISA. Moreover, this label-free approach offers a simple, and fast (~90 min) assay for direct IL-6 monitoring.

This study, “Label-free SERS for rapid identification of interleukin 6 based on intrinsic SERS fingerprint of antibody‑gold nanoparticles conjugate,” published in December 2023 in the International Journal of Biological Macromolecules, showcased the collaborative success between the University of Le Mans and the research centre TECNALIA thanks to authors Marjan Majdinasab, Aicha Azziz, Qiqian Liu, Verónica Mora-Sanz, Nerea Briz, Mathieu Edely and Marc Lamy de la Chapelle.

Read the publication here.

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General Assembly in Potsdam

From November 8-10, 2023, the DeDNAed consortium gathered for our M30 General Assembly, hosted by our partner the University of Potsdam.

The program started with work package presentations and discussion of the project’s progress, challenges and achievements. Members of our Advisory Board were present to provide valuable feedback, as well.

All partners then joined for hands-on experiments, delving deep into methodologies crucial for the development of our biosensing platform.

View some impressions from our General Assembly and group experiment here!

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Art exhibition uses DeDNAed and nanoparticles as inspiration

This summer, the Center for Microtechnologies, in collaboration with Fraunhofer ENAS and the Funken Academy 2023, gave 10 artists an insight into the research field of DNA-based nanotechnology.

The artist duo Carolin Liebl and Nikolas Schmid-Pfähler led the initiative, in which researchers from the Centre for Microtechnologies (ZfM) at the Technical University of Chemnitz accompanied artists through the complex research world of DNA origami, teaching them how to “shape the invisible”.

The scientists involved explained all the steps from the design, development and synthesis of a DNA origami to its deposition and “visualization” of the nano-objects by atomic force microscopy.

The artists then incorporated the impressions they had gathered into their works, which they presented at an exhibition on October 13 in cooperation with the Klub Solitaer on the campus of the Technische Universität Chemnitz.

We at DeDNAed are overwhelmed by the breadth of interpretations and creative ideas that emerged from this collaboration. Congratulations to all the talented artists involved!

(c) Johannes Richter
(c) Johannes Richter

View more images from the art installation on LinkedIn here.

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