The âAdvanced (Nano)Materials and Technologies: science, research & innovation for safety and sustainabilityâ Summit 2024 (ANTHOS 2024) promotes the advancements in technological innovation & research results on Safe-by-Design (SbD) for advanced (nano)materials and beyond.
In the field of medical diagnostics, the identification and measurement of biomarkers have become essential tools for early disease detection and treatment monitoring.
Within DeDNAed, Le Mans UniversitÃĐ (France) and the research centre TECNALIA Research & Innovation (Spain) focus their research on the detection of interleukin-6, a cytokine which can be used to monitor various human diseases and treatment responses. Conventional assays, such as ELISAs, are time-consuming and require large sample volumes. Therefore, the development of a fast, sensitive and selective detection method is critical.
Researchers from DeDNAed proposed a sensing method based on the surface-enhanced Raman scattering (#SERS), a technique that emerges as a promising alternative for the highly sensitive IL-6 detection.
They developed a label-free SERS immunoassay, achieving an impressive limit of detection of 0.91 pg mLâ1 (0.04 pM), ten times lower than ELISA. Moreover, this label-free approach offers a simple, and fast (~90 min) assay for direct IL-6 monitoring.
This study, “Label-free SERS for rapid identification of interleukin 6 based on intrinsic SERS fingerprint of antibodyâgold nanoparticles conjugate,” published in December 2023 in the International Journal of Biological Macromolecules, showcased the collaborative success between the University of Le Mans and the research centre TECNALIA thanks to authors Marjan Majdinasab, Aicha Azziz, Qiqian Liu, VerÃģnica Mora-Sanz, Nerea Briz, Mathieu Edely and Marc Lamy de la Chapelle.
Read the publication here.
From November 8-10, 2023, the DeDNAed consortium gathered for our M30 General Assembly, hosted by our partner the University of Potsdam.
The program started with work package presentations and discussion of the project’s progress, challenges and achievements. Members of our Advisory Board were present to provide valuable feedback, as well.
All partners then joined for hands-on experiments, delving deep into methodologies crucial for the development of our biosensing platform.
View some impressions from our General Assembly and group experiment here!
This summer, the Center for Microtechnologies, in collaboration with Fraunhofer ENAS and the Funken Academy 2023, gave 10 artists an insight into the research field of DNA-based nanotechnology.
The artist duo Carolin Liebl and Nikolas Schmid-PfÃĪhler led the initiative, in which researchers from the Centre for Microtechnologies (ZfM) at the Technical University of Chemnitz accompanied artists through the complex research world of DNA origami, teaching them how to “shape the invisibleâ.
The scientists involved explained all the steps from the design, development and synthesis of a DNA origami to its deposition and “visualization” of the nano-objects by atomic force microscopy.
The artists then incorporated the impressions they had gathered into their works, which they presented at an exhibition on October 13 in cooperation with the Klub Solitaer on the campus of the Technische UniversitÃĪt Chemnitz.
We at DeDNAed are overwhelmed by the breadth of interpretations and creative ideas that emerged from this collaboration. Congratulations to all the talented artists involved!
View more images from the art installation on LinkedIn here.
DeDNAed is developing a novel, innovative biosensing platform with benefits in terms of sensitivity, versatility and speed. This biosensor platform has four model interaction pairs: DNA-DNA, Aptamer-small molecule, peptide-protein and antibody-protein.
BNN Brings Nanomaterials to the Public at European Researchersâ Night 2023Â
Aitziber L. Cortajarena (CIC biomaGUNE) presented biofunctionalization work at BNN event on 13 September 2023 in Vienna, Austria.
On 29 August 2023, the DeDNAed project will host a workshop entitled âDeDNAed: Advancing Raman
Spectroscopy with DNA Origamiâ within the 4th European Biosensor Symposium in Aachen, Germany, on the campus of the FH Aachen University of Applied Sciences.
Last week (13. – 14. June 2023), BioCHIP Berlin 2023, an annual event focused on microfluidics technologies and applications, captivated attendees. Julia Hann (TUC) presented DeDNAed, while the DNA Origami builder garnered significant attention. This dynamic event showcased the potential of microfluidics in various sectors, fostering collaboration and inspiring groundbreaking discoveries. Exciting times lie ahead in the realm of microfluidics!
On 2 March 2023, Aicha Azziz (iMMM) was interviewed from the French radio show â15 MINUTES POUR COMPRENDREâ.
