DeDNAed featured in Spanish Perspectivas AseBio
The DeDNAed biosensor platform will be used to detect biomolecules, enabling the detection of food toxins or disease biomarkers.
Category: Project Outcomes
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Ultra-sensitive biosensor using DNA origami developed by 7 European partners
The DeDNAed biosensor platform will be used to detect biomolecules, enabling the detection of food toxins or disease biomarkers.
KSI produces DNA origami structures and hybrid structures
KSI Meinsberg, partner in DeDNAed, makes DNA origami and DNA origami hybrid structures for partners’ labs to measure.
UP includes biorecognition elements and analyte pairs in DeDNAed biosensor
In addition to coordinating the DeDNAed project, TU Chemnitz leads the âIntegration of DNA origami hybridsâ and âTransfer to flexible substrates and biosafetyâ. They are a bridge between the nanocomponents.
DeDNAed Final Webinar Recording
On 17 July 2024, the DeDNAed partners gathered online for our final dissemination webinar, entitled “Uniting disciplines: How DeDNAed combines physics and biology for novel biosensor development”.
Coordinator Danny Reuter (Technical University of Chemnitz) welcomed the participants and provided an overview of the DeDNAed project, its goals and consortium. Then Andreas Heerwig of the Kurt-Schwabe-Institut fÞr Mess- und Sensortechnik Meinsberg e.V. (KSI Meinsberg), explained “DNA origami as a tool for precise positioning of sensing elements towards quantitative SERS measurements”.
This was followed by our CIC biomaGUNE partner Itziar Galarreta-Rodriguez, who spoke about “ssDNA aptamers as biorecognition elements for DNA origami biosensor application”. Staying in San Sebastian, we then jumped to partner TECNALIA: VerÃģnica Mora Sanz explained “Antibody-protected bimetallic nanoclusters as biorecognition and transduction element in a DNA-origami based biosensor”.
The first section closed with Saloni Agarwal of University of Potsdam, speaking about “Characterising binding affinity of bio-recognition elements and their targets using switchSENSE technology.”
After a short break, we returned to Julia Voglhuber-HÃķller of BioNanoNet Forschungsgesellschaft mbH (BNN), who outlined “How Safe(-and-Sustainable)-by-Design can support innovations in the biosensor field”. She was followed by DeDNAed project manager Julia Hann, also of TU Chemnitz, who spoke about “Spatially resolved integration of heterogeneous DNA origami nanosystems on nanostructured surfaces for SERS”.
Finally, Aicha Azziz of the University of Le Mans explained “SERS detection of benzophenone using DNA origami hybrids”. The webinar was moderated by Caitlin Ahern of BNN.
The webinar attracted 50 live participants and ended with a Q&A session.
The recording can be viewed below!
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Coordinator TU Chemnitz integrates DNA origami hybrids
In addition to coordinating the DeDNAed project, TU Chemnitz leads the âIntegration of DNA origami hybridsâ and âTransfer to flexible substrates and biosafetyâ. They are a bridge between the nanocomponents.
BNN leads Safe-by-Design and dissemination activities for DeDNAed
DeDNAed partner BNN generates a Safe-by-Design (SbD) concept for the sensor platform. In addition, BNN manages the communication and dissemination activities for the H2020 project.
TECNALIA works with nanoclusters and plans the exploitation of DeDNAed
DeDNAed partner TECNALIA is working with antibodies decorated with nanoclusters as well as nanobodies. They also lead the exploitation of the project.
IMMM characterizes nanoparticles using SERS
The Institute of Molecules and Materials of Le Mans (IMMM) is in charge of the characterization of the optical and plasmonic properties of the nanostructures included in the bioanalytical platform. It also determines the SERS efficiency and the sensing performances of the platform. Finally, it is involved in the validation of the sensor for food and biomedical applications.
CIC biomaGUNE creates plasmonic particles and sensing elements
DeDNAed partner CIC biomaGUNE is responsible for design, synthesis, and characterization of different sensing biorecognition elements (antibodies and DNA aptamers) in pure state and modified with metallic and semiconductor atomic clusters. They also design, synthesize, and provide metallic nanoparticles of different size and shape as amplifiers of optical read out signals.
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