Category: Project Outcomes

Coordinator TU Chemnitz integrates DNA origami hybrids

In addition to coordinating the DeDNAed project, TU Chemnitz leads the “Integration of DNA origami hybrids” and “Transfer to flexible substrates and biosafety”. They are a bridge between the nanocomponents.

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BNN leads Safe-by-Design and dissemination activities for DeDNAed

DeDNAed partner BNN generates a Safe-by-Design (SbD) concept for the sensor platform. In addition, BNN manages the communication and dissemination activities for the H2020 project.

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TECNALIA works with nanoclusters and plans the exploitation of DeDNAed

DeDNAed partner TECNALIA is working with antibodies decorated with nanoclusters as well as nanobodies. They also lead the exploitation of the project.

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IMMM characterizes nanoparticles using SERS

The Institute of Molecules and Materials of Le Mans (IMMM) is in charge of the characterization of the optical and plasmonic properties of the nanostructures included in the bioanalytical platform. It also determines the SERS efficiency and the sensing performances of the platform. Finally, it is involved in the validation of the sensor for food and biomedical applications.

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CIC biomaGUNE creates plasmonic particles and sensing elements

DeDNAed partner CIC biomaGUNE is responsible for design, synthesis, and characterization of different sensing biorecognition elements (antibodies and DNA aptamers) in pure state and modified with metallic and semiconductor atomic clusters. They also design, synthesize, and provide metallic nanoparticles of different size and shape as amplifiers of optical read out signals.

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First Joint Publication for DeDNAed

In the field of medical diagnostics, the identification and measurement of biomarkers have become essential tools for early disease detection and treatment monitoring.

Within DeDNAed, Le Mans Université (France) and the research centre TECNALIA Research & Innovation (Spain) focus their research on the detection of interleukin-6, a cytokine which can be used to monitor various human diseases and treatment responses. Conventional assays, such as ELISAs, are time-consuming and require large sample volumes. Therefore, the development of a fast, sensitive and selective detection method is critical.

Researchers from DeDNAed proposed a sensing method based on the surface-enhanced Raman scattering (#SERS), a technique that emerges as a promising alternative for the highly sensitive IL-6 detection.

They developed a label-free SERS immunoassay, achieving an impressive limit of detection of 0.91 pg mL−1 (0.04 pM), ten times lower than ELISA. Moreover, this label-free approach offers a simple, and fast (~90 min) assay for direct IL-6 monitoring.

This study, “Label-free SERS for rapid identification of interleukin 6 based on intrinsic SERS fingerprint of antibody‑gold nanoparticles conjugate,” published in December 2023 in the International Journal of Biological Macromolecules, showcased the collaborative success between the University of Le Mans and the research centre TECNALIA thanks to authors Marjan Majdinasab, Aicha Azziz, Qiqian Liu, Verónica Mora-Sanz, Nerea Briz, Mathieu Edely and Marc Lamy de la Chapelle.

Read the publication here.

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