• PROJECT
    • PROJECT SUMMARY
    • OBJECTIVES
    • WORK PLAN
  • CONSORTIUM
  • NEWS & MEDIA
  • PUBLICATIONS
  • CONTACT
Twitter Linkedin-in

Type To Search

  • PROJECT
    • PROJECT SUMMARY
    • OBJECTIVES
    • WORK PLAN
  • CONSORTIUM
  • NEWS & MEDIA
  • PUBLICATIONS
  • CONTACT
Twitter Linkedin-in

Type To Search

  • PROJECT
    • PROJECT SUMMARY
    • OBJECTIVES
    • WORK PLAN
  • CONSORTIUM
  • NEWS & MEDIA
  • PUBLICATIONS
  • CONTACT

Type To Search

  • PROJECT
    • PROJECT SUMMARY
    • OBJECTIVES
    • WORK PLAN
  • CONSORTIUM
  • NEWS & MEDIA
  • PUBLICATIONS
  • CONTACT
Press release
27 MayNews

Press release

EU H2020 FET Open project DeDNAed

DeDNAed – Cluster decorated recognition elements on DNA origami for enhanced Raman spectroscopic detection methods

DeDNAed started on March 1st, 2021 with a duration of 36 months.

What is DeDNAed about? What are its objectives?

The project “DeDNAed” intends to develop a novel, innovative biosensing platform whose advantages and benefits are in terms of sensitivity, versatility and being ultrafast by an optical approach. Our platform will be based on the assembly and integration of sensing elements (transducer and bioreceptor) by DNA origami. The DNA origami will serve as a “nano breadboard” in order to precisely control the position of these elements and thus the sensor architecture at the nanometer scale.

Metallic atomic clusters are integrated into a biological marker molecule (DNA or antibody) and thus represent the biological sensor element. This is specifically integrated into a nanoarray made of additional metallic nanoparticles precisely controlled by a DNA origami template and will lead to a significant increase in signal. DNA origami serves as an individually inter- and intramolecularly programmable “nano breadboard”. A DNA origami consists of a single strand of DNA, folded by a thermal treatment and certain staple strands into any shapes (2D as well as 3D, dimensions of approx. 100 nanometers). So-called “sticky ends” on the surface of the DNA origami offer the possibility of an individual implementation of the sensing elements and nanoparticles, by means of correspondingly complementary oligonucleotides with a resolution of approx. 2 nm. When the analyte binds to the sensor element, a change in the Raman signal can be detected without major delay using surface-enhanced Raman spectroscopy (SERS). This sensor method is not limited to a specific biomarker molecule for the sensor element, but can be transferred to different marker molecules. This results in a high degree of flexibility in the area of application, reaching from medical technology to food monitoring. In addition, a transfer of the DNA origami-based sensor platform to flexible, textile substrates will be developed using lipid bi-layers and the Langmuir-Blodgett method for later use as a wipe test or medical wearable.

Who are DeDNAed’s beneficiaries?

Seven beneficiaries from four different countries collaborate in the DeDNAed project

  • TECHNISCHE UNIVERSITAET CHEMNITZ (Project Coordinator, Germany)
  • ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE (Spain)
  • KURT-SCHWABE-INSTITUT FUR MESS- UND SENSORTECHNIK MEINSBERG EV (Germany)
  • UNIVERSITE DU MANS (France)
  • UNIVERSITAET POTSDAM (Germany)
  • FUNDACION TECNALIA RESEARCH & INNOVATION (Spain)
  • BIONANONET FORSCHUNGSGESELLSCHAFT MBH (Austria)
Share article:
Press release

DeDNAed Kick-off meeting

March 18, 2021

DeDNAed @ BNN newsletter (July 2021)

July 9, 2021

Related Posts

27 JunNews

Workshop on integration of DNA origami performed at University of Potsdam

Read More
30 JunNews

DeDNAed @ BNN Quarterly (June 2022)

Read More
Recent Posts
  • DeDNAed @ MAIN General Assembly
    November 4, 2022
    On October 10, Mathis Janßen (TUC) presented...
  • Towards safe innovations in Nanodiagnostics
    October 19, 2022
    The DeDNAed project is guided by safety and...
  • DeDNAed consortium meets in Chemnitz for 4th General Assembly
    October 13, 2022
    From 28-29 September 2022, members of the...
Categories
  • Events(2)
  • News(12)
Tags
conference consortium meeting dna flyer general assembly Kick-off newsletter Press release social media webinar workshop
Our latest tweets

AvatarDeDNAed@DeDNAed_project·
22 Dec

Hope your holidays are filled with as much good cheer as a dancing #DNAorigami tree!

All the best for the new year from the DeDNAed project team!

@EU_HaDEA @CICbiomaGUNE @TUChemnitz @LeMansUniv @bionanonet @tecnalia @unipotsdam

AvatarDeDNAed@DeDNAed_project·
16 Dec

Follow the #12DaysofNanomaterials from @bionanonet to learn the basics about Gold nanoparticles (used in our biosenosrs) and other nanoparticles used in a variety of applications. ðŸĪ“

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 964248

Legal Notice  |  Privacy Policy
BACK TO TOP